Aquaculture Drug Update

———- Forwarded message ———-
From: <Thomas_A_Bell@fws.gov>
Date: Fri, Apr 13, 2012 at 2:50 AM
Subject: New Aquaculture Drug Update (12 April 2012)
To:

Hello all,

Please find below a link to the most recent “Aquaculture Drug Update” that is being published today, Thursday 12 April 2012.

http://www.fws.gov/fisheries/aadap/2012%20Updates.htm

For those of you that manage a listserve or other such similar email lists, we appreciate your willingness to distribute this to your members. For everyone else, please feel free to distribute this to anyone who you feel will benefit from the information. Please be sure to include the entire Update, including links.

In addition to the Update being available via the above noted link, below is the entire text to the Update (although the links are not active).

Thanks much in advance.

Cheers.

(See attached file: New Aquaflor label claims 12April2012 .doc)(See attached file: New Aquaflor label claims 12April2012.pdf)

Thomas A. Bell, PhD
U.S. Fish & Wildlife Service
Aquatic Animal Drug Approval Partnership
4050 Bridger Canyon Road
Bozeman, Montana 59715
Phone: 406-994-9911
Fax: 406-582-0242
Email: thomas_a_bell@fws.gov
Webpage: http://fisheries.fws.gov/aadap


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Yours sincerely,Dr Richmond Loh
BSc BVMS MPhil (Vet Path) MANZCVS (Aquatics & Pathobiology) DipPM

Veterinarian / Adjunct Lecturer Murdoch University / Secretary Aquatic Animal Health Chapter ANZCVS
The Fish Vet, Perth, Western Australia. Mobile Veterinary Service for fish and other aquatic creatures.
http://www.thefishvet.com.au
Ph: +61 (0)421 822 383

Ever wondered why your fingers become wrinkly when you’ve been in water for a while?

You might say you know it. It’s because of osmosis where your skin absorbs the water and your hands turn ‘pruny’. But this latest research finding ‘blows that theory out if the water’!

http://www.nature.com/news/2011/110628/full/news.2011.388.html

What’s your pH? More importantly, what’s your KH?

In Perth we are fairly lucky with our tap water that it already comes with ~70mg/L of KH (carbonate hardness also known as [the pH] buffering capacity of water). Sometimes a bit more, sometimes a bit less. Provided that we carry out regular aquarium maintenance, we ought not run into issues with pH becoming too acidic because this level of KH should buffer against this. But did you know that this KH will be consumed and decrease over time? When this happens, your pH can fluctuate wildly, causing stress to the fish. Depending on several factors, your pH could drop to as low as 4.5! Very nasty for many fish.

What are some clues that might lead you suspect this could be occurring? Those species intolerant of low pH will develop excess white opaque mucus over their bodies and around the edges of their gill covers. They would become lethargic and hold their fins clamped to their body. The base of Their fins, especially their pectoral and pelvic fins will become congested. Fish will appear disoriented and lose interest in food. You will start to lose fish.

A quick water test would reveal a very low pH. Then a quick KH test would point to the reason for the low pH.

What to do? You will need to act quickly and slowly at the same time. ????

Act quickly to obtain buffering salts. But act slowly in terms of gradually increasing the KH and pH so as not to create more stress in the fish. Speak with your veterinarian or local fish shop for advice on the best combination of buffers for your individual system.

What are common sequelae such a condition? Fish may succumb to secondary bacterial infection and so antibiotics may be indicated.

The bio-filter may be destroyed by the low pH and so you’ll need to treat your system as a “new tank” in terms of the nitrogen cycle.

Also a note of warning whenever you use antibiotics is that it will whack your bio filter around and so it is very important that you conduct daily water testing especially for levels of ammonia and nitrite. Feeding should be reduced while the biofilter re-establishes itself, water changes conducted as necessary and bacteria starter cultures may be indicated at the completion of treatment.

Make sure you get a good set of water test kits.

Need antibiotics for your fish? Really? Which one?

Very often fish keepers call on veterinarians because they are convinced that they need antibiotics for their sick fish…. after consulting doctor Google. What is the issue with this?

For one thing, antibiotics may not be indicated as the treatment for the condition. There are really very many reasons why fish get sick. Could it be water quality issues? Different parasitic conditions? Virus? Stress? Trauma? Cancer? Notice that GPs do not simply dish out antibiotics at every consultation?

Why not? This paper details a very pertinent reason. High levels of resistance have been reported to amoxicillin, penicillin, tetracycline and oxytetracycline. I concur with this from all the lab testing I have conducted. Where indicated, my first line antibiotic would not include these drugs.

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Zoonotic bacteria, antimicrobial use and antimicrobial
resistance in ornamental fish: a systematic review
of the existing research and survey of aquaculture-
allied professionals
Weir M, A Rajic, L Dutil, N Cernicchiaro, FC Uhland, B
Mercier & N Tusevljak (2012). Epidemiology & Infection,
140 (2): 192 – 206.
Abstract
Using systematic review methodology, global research
reporting the frequency of zoonotic bacterial
pathogens, antimicrobial use (AMU) and antimicrobial
resistance (AMR) in ornamental fish, and human illness
due to exposure to ornamental fish, was examined. A
survey was performed to elicit opinions of aquacultureallied
personnel on the frequency of AMU and AMR in
ornamental fish.
The most commonly reported sporadic human infections
were associated with Mycobacterium marinum,
while Salmonella Paratyphi B var. Java was implicated
in all reported outbreaks. Aeromonas spp. were most
frequently investigated (n=10 studies) in 25 studies surveying
ornamental fish from various sources. High levels
of resistance were reported to amoxicillin, penicillin,
tetracycline and oxytetracycline, which was also in
agreement with the survey respondents’ views.
Studies on AMU were not found in our review. Survey
respondents reported frequent use of quinolones,
followed by tetracyclines, nitrofurans, and aminoglycosides.

Recommendations for future surveillance and
public education efforts are presented

Fish and salt. Too much of a good thing?

One of the first line therapies for sick fish is adding salt to the water at low concentrations. It is also useful at high concentrations as a dip to remove external parasites from the fishes. But how do the fish cope with this?

This paper shows that too much of a good thing causes fish stress.

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Clinical and Physiologic Effects of Sodium Chloride
Baths in Goldfish (Carassius auratus)
Burgdorf-Moisuk A, MA Mitchell & M Watson (2011). J.
Zoo Wildlife Med., 42(4): 586-592.
Abstract
Sodium chloride (salt; NaCl) has been used for
freshwater fish to decrease stress and manage a variety
of disease conditions. Recommendations for dose
and duration vary greatly. The purpose of this study
was to determine the potential adverse clinical and
physiologic side effects of different concentrations of
saltwater baths on goldfish.
Eleven goldfish (Carassius auratus) were used in a
cross-over study to assess the effects of three different
salt concentrations (5, 10, and 20 g/L) on plasma biochemistries
and clinical response. Baseline plasma
chemistries were obtained and analyzed immediately
prior to placing the goldfish into the saltwater bath and

after the fish was removed. A 2-wk washout period was
used in-between each treatment. Significant differences
were found in fish in the sodium (10 g/L, P = 0.007; 20
g/L, P = 0.01), chloride (10 g/L, P = 0.006; 20 g/L, P =
0.001), and alanine aminotransferase (10 g/L, P =
0.002; 20 g/L, P = 0.004) after their exposure to 10 and
20 g/L saltwater. Glucose levels were found to differ
significantly after exposure to all three NaCl concentrations
(5 g/L, P = 0.0009; 10 g/L, P = 0.0001; 20 g/L, P =
0.0005). Clinically, 5 g/L and 10 g/L saltwater baths
were well tolerated by the fish for the duration of the
intended 12-hr treatments, with only one goldfish being
removed during the 10 g/L bath at 7 hr for listlessness.
The average time goldfish spent in the 20 g/L salt bath
was 43 min, with six (54%) of the fish remaining in the
20 g/L salt bath for the intended 60-min treatment period.
The remaining 5 (46%) goldfish were removed
because they became listless or dyspneic. All of the
fish recovered from the treatments without complication.
The results of this study suggest that goldfish tolerate
saltwater baths but that physiologic disturbances
can occur at the higher doses.

Black fish for black Friday?

It’s Friday the 13th today.
Is it a lucky day or a bad luck day?

Fish are sometimes kept as a good luck charms. Some Chinese rear 8 gold fish and 1 black fish. The 8 gold ones are to bring prosperity and the one black fish is to ward off evil spirits.

I quite like Friday 13th because I was born on such a date!