Nitrite toxicity in sturgeon.

What coincidence! I consulted with a client today about nitrite toxicity that occurred 2 weeks after he’d cleaned his filter a little too thoroughly using tap water!

Also, one of the co-authors, Dr Emily Donaldson is a colleague I met during Aquavet II last June!

Journal of Fish Diseases
Volume 35, Number 12 (December 2012)
	Effect of chloride on nitrite-induced methaemoglobinemia in Atlantic sturgeon, Acipenser oxyrinchus oxyrinchus(Mitchill)
	Authors:	M A Matsche, E Markin, E Donaldson, A Hengst, A Lazur
	Author Affiliations:	no affiliations available
	Source:	Journal of Fish Diseases, Volume 35, Number 12 (December 2012)
	Page Numbers:	873 – 885
	Available Full Text:	Full Text: Subscription Required to view full text Format: PDF Size: unknown Location: Publisher’s Site Authentication: EBSCOhost EJS
	Abstract:	We evaluated the effects of chloride concentration on the clinical pathology in juvenile Atlantic sturgeon, Acipenser oxyrinchus oxyrinchus(Mitchill),following semi-static exposures to 1 mg L-1nitrite for 96 h. In spring water naturally low in chloride (5 mg L-1), plasma nitrite concentrated to more than 40× environmental levels resulting in a severe methaemoglobinemia characterized by torpid behaviour, 30-fold increase in methaemoglobin fraction, anaemia, leucopenia and hyperkalaemia. Loss of intracellular water and potassium to extracellular space may have resulted in hyperkalaemia and haemodilution. Fish survived nitrite exposure, but 60% of torpid fish died following capture and tissue sampling. Fish acclimated to 10-fold higher chloride content (55 mg L-1) did not concentrate nitrite in the plasma above environmental levels or develop methaemoglobinemia, but did exhibit similar haematology and plasma chemistry changes. Plasma nitrite returned to preexposure levels by 14 days following nitrite exposures, but severity of clinical pathology changes persisted or increased, suggesting that Atlantic sturgeon have reduced capacity to recover from methaemoglobinemia. Fish that survive methaemoglobinemia may be susceptible to mortality from the cumulative effects of intoxication, handling and other stresses for two or more weeks following nitrite remediation. Chloride buffering in aquaculture systems reduces the toxic effects of nitrite accumulation.
	Citation:	M A Matsche, E Markin, E Donaldson, A Hengst, A Lazur . Effect of chloride on nitrite-induced methaemoglobinemia in Atlantic sturgeon, Acipenser oxyrinchus oxyrinchus(Mitchill). Journal of Fish Diseases, Volume 35, Number 12 (December 2012), pp. 873-885, <http://ejournals.ebsco.com/direct.asp?ArticleID=486DAA50900EBDFBB1BD&gt;
	URL:	http://ejournals.ebsco.com/direct.asp?ArticleID=486DAA50900EBDFBB1BD